Recombinant live feline immunodeficiency virus and proviral...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 39/21 (2006.01) A61K 48/00 (2006.01) C07K 14/155 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/49 (2006.01) C12N 15/867 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2247091

This invention discloses live-attenuated feline immunodeficiency virus (FIV), and recombinant vectors for producing them, useful as vaccines and therapeutic agents against FIV and diseases associated with virulent FIV infection. In the recombinant vectors and FIVs, one or more genes, or part of the gene(s), responsible for FIV pathogenesis have been completely or partially rendered nonfunctional, e.g., by full or partial deletion or mutagenesis. These anti- FIV vaccines may be given to susceptible hosts in the form of infectious virus or cloned DNA.

Cette invention se rapporte à des virus de l'immunodéficience féline (VIF) vivants atténués, et à des vecteurs recombinés pour produire ces virus, utiles comme vaccins et comme agents thérapeutiques contre le VIF et les maladies associées à une infection par VIF virulent. Dans ces vecteurs recombinés et ces virus de l'immunodéficience féline, un ou plusieurs gènes, ou une partie de ce ou ces gènes, responsables de la pathogenèse au VIF, ont été complètement ou partiellement rendus non fonctionnels, notamment par mutagenèse ou délétion complète ou partielle. Ces vaccins anti-VIF peuvent être administrés à des hôtes susceptibles de les recevoir sous la forme de virus infectieux ou d'ADN clonés.

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