Recombinant marek's disease virus, process for preparing the...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/01 (2006.01) A61K 39/17 (2006.01) A61K 39/255 (2006.01) C07K 14/055 (2006.01) C07K 14/125 (2006.01) C12N 15/86 (2006.01) C12N 15/869 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2073493

The present invention is directed to a recombinant Marek's disease virus produced by mutation of a Marek's disease virus with a plasmid wherein said plasmid comprises (1) a gene fragment derived from the Us region or inverted repeat sequences adjacent to both ends of said Us region of a Marek's disease virus genome and (2) an exogenous gene expression cassette incorporated in said gene fragment, said cassette comprising an exogenous gene bound downstream of a promoter derived from an animal cell or an animal virus. The invention is further directed to a process for preparing the same, a multivalent live vaccine for birds comprising the same, and a vector for administration of a physiologically active substance to birds comprising the same.

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