Recombinant megalomicin biosynthetic genes and uses thereof

Details Recombinant megalomicin biosynthetic genes and uses thereof Recombinant megalomicin biosynthetic genes and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/52 (2006.01) C12N 9/04 (2006.01) C12N 9/10 (2006.01) C12N 9/90 (2006.01) C12N 15/53 (2006.01) C12N 15/54 (2006.01) C12N 15/61 (2006.01) C12N 15/62 (2006.01) C12P 19/62 (2006.01)

Patent

CA 2383969

Recombinant nucleic acid, e.g DNA compounds that encode all or a portion of the megalomicin polyketide synthase and modification enzymes are used to express recombinant polyketide synthase genes in host cells for the production of megalomicin, megalomicin derivatives, and other polyketides that are useful as antibiotics, motilides, and antiparasitics.

De l'acide nucléique de recombinaison, par exemple des composés d'ADN codant la totalité ou une partie de la polycétide synthase de mégalomicine et des enzymes de modification sont utilisés pour exprimer des gènes de polycétide synthase de recombinaison dans des cellules hôtes pour produire de la mégalomicine, des dérivés de mégalomicine et d'autres polycétides qui sont utiles en tant qu'antibiotiques, motilides et antiparasitaires.

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