C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) C07K 14/16 (2006.01)
Patent
CA 2740237
A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide.
Accornero Federica
Brancaccio Mara
Carnevale Daniela
Lembo Giuseppe
Tarone Guido
Macrae & Co.
Target Heart Biotec S.r.l.
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