C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) C07D 417/06 (2006.01) C07D 493/04 (2006.01) C07D 493/08 (2006.01) C07D 498/08 (2006.01) C07D 513/08 (2006.01) C12N 15/52 (2006.01) C12P 17/06 (2006.01) C12P 17/18 (2006.01)
Patent
CA 2350189
Recombinant nucleic acids that encode all or a portion of the epothilone polyketide synthase (PKS) of sorangium cellulosum are used to express recombinant PKS genes in host cells for the production of epithilones, epothilone derivatives, and polyketides that are useful as cancer chemotherapeutics, fungicides, and immunosuppressants.
Selon cette invention, des acides nucléiques recombinants qui codent pour la synthase de polycétides d'épothilones (PKS), intégralement ou en partie, sont utilisés pour exprimer les gènes de la PKS recombinante dans des cellules hôtes à des fins de fabrication d'épothilones, de dérivés d'épothilones et de polycétides utiles en tant qu'agents chimiothérapeutiques destinés au traitement du cancer ou utilisés en tant que fongicides ou immunosuppresseurs.
Julien Bryan
Katz Leonard
Khosla Chaitan
Tang Li
Ziermann Rainer
Gowling Lafleur Henderson Llp
Kosan Biosciences Inc.
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