C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/74 (2006.01) C12N 1/21 (2006.01) C12P 7/46 (2006.01)
Patent
CA 2592449
Disclosed are recombinant microorganisms for producing organic acids. The recombinant microorganisms express a polypeptide that has the enzymatic activity of an enzyme that is utilized in the pentose phosphate cycle. The recombinant microorganism may include recombinant Actinobacillus succinogenes that has been transformed to express a Zwischenferment (Zwf ) gene. The recombinant microorganisms may be useful in fermentation processes for producing organic acids such as succinic acid and lactic acid. Also disclosed are novel plasmids that are useful for transforming microorganisms to produce recombinant microorganisms that express enzymes such as Zwf.
Micro-organismes de recombinaison pour une production accrue d'acides organiques, qui expriment un polypeptide ayant l'activité enzymatique d'une enzyme utilisée dans le cycle du pentose phosphate. Ledit micro-organisme de recombinaison peut contenir Actinobacillus succinogenes recombiné qui a été transformé pour exprimer un gène Zwischenferment (Zwf). Il peut être utile dans des processus de fermentation pour produire des acides organiques tels que de l'acide succinique et de l'acide lactique. La présente invention concerne également de nouveaux plasmides utiles pour transformer des micro-organismes et obtenir des micro-organismes de recombinaison qui expriment des enzymes telles que Zwf.
Guettler Michael V.
Kleff Susanne
Yi Jian
Gowling Lafleur Henderson Llp
Michigan Biotechnology Institute
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