C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/29 (2006.01) A01H 5/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) C07K 14/42 (2006.01) C07K 16/16 (2006.01) C07K 19/00 (2006.01) C12N 15/82 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A01N 65/00 (2006.01)
Patent
CA 2225924
The invention relates to nucleic acid molecules encoding preproproteins having after maturation the biological activity of the mistletoe lectin dimer, to vectors comprising these nucleic acid molecules, to hosts transformed with said vectors and to polypeptides and/or polypeptide dimers which are encoded by these nucleic acid molecules. The polypeptides and/or polypeptide dimers of the invention are widely therapeutically applicable. Thus, the present invention further relates to immunotoxins as well as to pharmaceutical compositions that contain the polypeptides and/or the polypeptide dimers of the invention. Additionally, the invention relates to diagnostic compositions comprising the nucleic acid molecules of the invention, the polypeptides and/or the polypeptide dimers of the invention and/or primers which hybridize specifically to the nucleic acid molecules of the invention. Finally, the invention relates to plant protective agents comprising the polypeptides of the invention and/or the polypeptide dimers of the invention.
L'invention concerne des molécules d'acide nucléique qui codent des préproprotéines et qui, après maturation, présentent l'activité biologique des dimères de lectine de gui, des vecteurs qui contiennent ces molécules d'acide nucléique, des hôtes transformés avec ces vecteurs et des polypeptides ou dimères polypeptidiques, codés par ces molécules d'acide nucléique. Les polypeptides et dimères polypeptidiques de l'invention peuvent avoir de nombreuses applications thérapeutiques. Par conséquent, l'invention concerne également des immunotoxines et médicaments qui contiennent les polypeptides ou dimères polypeptidiques de l'invention. En outre, l'invention concerne des compositions diagnostiques qui contiennent les molécules d'acide nucléique de l'invention, les polypeptides ou dimères polypeptidiques de l'invention et/ou des amorces qui s'hybrident spécifiquement sur les molécules d'acide nucléique de l'invention. L'invention concerne finalement des produits phytosanitaires qui contiennent les polypeptides et/ou dimères polypeptidiques de l'invention.
Baur Axel
Eck Jurgen
Lentzen Hans
Zinke Holger
Madaus Ag
Ridout & Maybee Llp
Viscum Ag
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