Recombinant monoclonal antibodies

C - Chemistry – Metallurgy – 12 – N

Patent

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167/139, 195/1.1

C12N 5/02 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) C12N 15/00 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1190873

ABSTRACT OF THE DISCLOSURE Novel recombinant monoclonal antibodies that have binding affinities for two different antigens within a single antibody molecule are described. The antibodies are formed by incubating a quadroma cell or a trioma cell, and separating soluble protein. The antibodies may be used in analytical and diagnostical techniques, targeted delivery of biological and pharmacologic agents to specific cells and the identification and localization of specific antigens, receptors and cell surface substances.

406425

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