Recombinant mutants for inducing specific immune responses

Details Recombinant mutants for inducing specific immune responses Recombinant mutants for inducing specific immune responses

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/10 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) C07K 14/005 (2006.01) C07K 14/105 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C07K 14/495 (2006.01) C07K 14/54 (2006.01) C07K 14/55 (2006.01) C12N 9/88 (2006.01) C12N 15/31 (2006.01) C12N 15/40 (2006.01) C12N 15/60 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2133999

2133999 9321324 PCTABS00027 A recombinant plasmid comprises the cyaC and the cyaA genes of Bordetella which directs the expression of Bordetella, adenylate cyclase in a transformed host cell. A recombinant DNA molecule can comprise the Bordetella cyaA gene containing at least one insertion of a heterologous DNA sequence at at least one permissive site. In addition, a recombinant Bordetella adenylate cyclase comprises a heterologous epitope at a permissive site. Methods of inducing a specific B cell, helper T cell, and CTL cell immune response are provided.

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