C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61K 39/39 (2006.01) C07K 1/14 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 15/67 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2480786
In this application is described the expression and purification of a recombinant Plasmodium falciparum (FVO) MSP-142 The method of the present invention produces a highly purified protein that retains folding and disulfide bridging of the native molecule. The recombinant MSP-142 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.
La présente invention concerne l'expression et la purification d'une protéine 1¿42? de surface de mérozoïte (MSP-1¿42?) anti Plasmodium falciparum (FVO) de recombinaison. Le procédé selon cette invention consiste à produire une protéine hautement purifiée qui conserve le repliement et les liaisons disulfure de la molécule native. La MSP-1¿42? de recombinaison selon cette invention est utilisée comme réactif de diagnostic, dans la production d'anticorps et en tant que vaccin.
Angov Evelina
Cohen Joe D.
Darko Christian Asare
Lyon Jeffery A.
Borden Ladner Gervais Llp
Glaxosmithkline Biologicals S.a.
Government Of The United States As Represented By The Secretary Of The Army
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