Recombinant p. vivax merozoite protein-1 p42 vaccine

Details Recombinant p. vivax merozoite protein-1 p42 vaccine Recombinant p. vivax merozoite protein-1 p42 vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/30 (2006.01) A61K 39/015 (2006.01) A61K 47/42 (2006.01) A61P 33/06 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12P 21/02 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2443947

In this application is the expression and purification of a recombinant Plasmodium vivax (SalI) PvMSP-1 p42. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant PvMSP-1 p42 is useful as a diagnostic reagent, for use in antibody production, and as a vaccine.

La présente invention concerne l'expression et la purification d'un Plasmodium vivax (SalI) PvMSP-1 p42 recombinant. La méthode de l'invention permet de produire une protéine hautement purifiée qui conserve le repliement et la formation de liaison disulfure de la molécule native. Le PvMSP-1 p42 recombinant est utile en tant que réactif de diagnostic, et peut être utilisé pour la production d'anticorps ou comme vaccin.

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