A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) C12N 15/861 (2006.01) C07K 14/47 (2006.01) C12N 7/01 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2174556
Described are simplified and efficient methods for preparing recombinant adenovirus using liposome-mediated cotransfection and the direct observation of a cytopathic effect (CPE) in the transfected cells. Also disclosed are compositions and methods involving novel p53 adenovirus constructs, including methods for restoring p53 function and tumor suppression in cells and animals having abnormal p53.
Procédés simplifiés et efficaces de préparation d'un adénovirus recombiné par cotransfection induite par liposomes, et d'observation directe d'un effet cytopathique dans les cellules transfectées. L'invention concerne également des compositions et procédés dans lesquels sont impliqués de nouveaux produits d'assemblage d'adénovirus p53, y compris des procédés permettant de rétablir la fonction p53 et d'éliminer des tumeurs dans des cellules et chez des animaux à fonction p53 anormale.
Roth Jack A.
Zhang Wei-Wei
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
Board Of Regents University Of Texas System
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