Recombinant parainfluenza virus expression systems and vaccines

Details Recombinant parainfluenza virus expression systems and vaccines Recombinant parainfluenza virus expression systems and vaccines

A - Human Necessities

01

N

A01N 63/00 (2006.01) A61K 39/155 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2403701

The present invention relates to recombinant bovine parainfluenza virus (bPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

L'invention concerne de l'ADNc ou de l'ARN du virus parainfluenza bovin recombiné (bPIV), pouvant être utilisé pour l'expression de produits géniques hétérologues dans des systèmes cellulaires hôtes appropriés et/ou comme antidote électif des virus de recombinaison à ARN à souche négative, exprimant, enveloppant et/ou présentant ledit produit génique hétérologue. Les virus chimères et les produits d'expression peuvent être utilisés avantageusement dans des préparation vaccinales comprenant des vaccins contre une plage étendue de pathogènes et d'antigènes.

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