Recombinant perforin, expression and uses thereof

Details Recombinant perforin, expression and uses thereof Recombinant perforin, expression and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/867 (2006.01)

Patent

CA 2558178

The present invention relates to retroviral vectors capable of driving the expression of perforin in a cell and a method of expressing recombinant perforin in a cell. The present invention also relates to recombinant perforin polypeptides and nucleic acid molecules derived therefrom and uses thereof. Also encompassed are screening assays employing such recombinant perforin molecules, compounds identified by the screening assays and uses thereof.

La présente invention concerne des vecteurs rétroviraux capables de diriger l'expression de la perforine dans une cellule et une méthode d'expression d'une perforine de recombinaison dans une cellule. L'invention concerne également des polypeptides de perforine de recombinaison et des molécules d'acides nucléiques dérivés desdits polypeptides, et leurs utilisations. Sont décrits en outre des essais de criblage faisant intervenir de telles molécules de perforine de recombinaison ainsi que des composés identifiés au terme de ces essais et leurs utilisations.

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