C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/20 (2006.01) A61K 35/66 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 39/40 (2006.01) A61K 39/44 (2006.01) A61P 31/00 (2006.01) C07K 14/01 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12N 15/13 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2244792
The present invention relates to bacteriophages for use in the treatment or prophylaxis of bacterial infections, especially mucosal bacterial infections such as Helicobacter pylori infections. In particular, it relates to modified filamentous bacteriophages, e.g. M13 phages, for such use, which bacteriophages present at its surface a recombinant protein comprising: (i) a first component derived from a bacteriophage surface protein; and (ii) a second component comprising variable region sequences of an antibody to provide a bacterial antigen binding site, said second component rendering said bacteriophage capable of binding to and thereby inhibiting growth of bacterial cells involved in the etiology of said infection.
Bactériophages destinés au traitement ou à la prévention des infections bactériennes, notamment des infections bactériennes des muqueuses comme les infections par Helicobacter pylori. L'invention porte en particulier sur des bactériophages filamenteux modifiés, comme les phages M13 destinés à une telle utilisation, qui présentent sur leurs surfaces une protéine de recombinaison comprenant: i) un premier composant issu d'une protéine de surface de bactériophage; et ii) un deuxième composant comprenant des séquences de régions variables d'un anticorps offrant un site de liaison aux antigènes bactériens, ce deuxième composant ayant pour effet de rendre le bactériophage apte à se lier à des cellules bactériennes impliquées dans l'étiologie de cette infection et à empêcher ainsi la croissance de ces cellules.
Phagen Ab
Robic
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