Recombinant phages capable of entering host cells via...

Details Recombinant phages capable of entering host cells via... Recombinant phages capable of entering host cells via...

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) C07K 16/00 (2006.01) C12N 9/22 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2385664

The invention relates to a genetically modified bacteriophage, pseudovirion or phagemid capable of entering a host cell by binding of its artificial ligand to an artificial receptor present on said host cell. The invention relates also to the use of the genetically modified bacteriophage, pseudovirion or phagemid and of the host cell to screen sequence libraries, including antibody library.

L'invention concerne un bactériophage, pseudovirion, ou phagémide génétiquement modifié capable de pénétrer dans une cellule hôte par liaison de son ligand artificiel à un récepteur artificiel présent sur ladite cellule hôte. L'invention concerne également l'utilisation de ce bactériophage, pseudiovirion ou phagémide génétiquement modifié et de la cellule hôte pour le criblage de banques de séquences, notamment une banque d'anticorps.

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