C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61K 39/42 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2638833
Disclosed are novel polyclonal antibodies, which target respiratory syncyticilal virus (RSV), and novel high affinity antibody molecules reactive with RSV. The polyclonal antibodies may comprise antibody molecules which are reactive with both RSV protein F and RSV protein G, and preferably the polyclonal antibodies target a variety of epitopes on these proteins. The single antibody molecules of the invention are shown to exhibit affinities which provide for dissocation constants as low as in the picomolar range. Also disclosed are methods of producing the antibodies of the invention as well as methods of their use in treatment for RSV infection.
L'invention concerne de nouveaux anticorps polyclonaux, qui ont pour cible le virus respiratoire syncytial (VRS), ainsi que des molécules d'anticorps à affinité élevée réagissant au VRS. Les anticorps polyclonaux peuvent comprendre des molécules d'anticorps qui réagissent aussi bien à la protéine F du VRS qu'à la protéine G du VRS, les anticorps polyclonaux ciblant, de préférence, une variété d'épitopes sur ces protéines. Les molécules d'anticorps simples selon l'invention présentent des affinités qui prévoient des constantes de dissociation infimes de l'ordre du picomolaire. L'invention concerne également des procédés de production desdits anticorps ainsi que leurs procédés d'utilisation dans le traitement de l'infection du VRS.
Koefoed Klaus
Lantto Johan
Nielsen Henriette Schjonning
Nielsen Lars S.
Steinaa Lucilla
Sim & Mcburney
Symphogen A/s
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