C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/15 (2006.01) A61K 38/57 (2006.01) A61K 39/395 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2041638
This invention relates to PAI-2 and its expression as a recombinant molecule in eukaryotic cell lines as a glycosylated secreted molecule, to the constructs expressing it, to host cells expressing it, to compositions comprising it, to methods of treatment, prophylaxis and diagnosis using it and to antibodies raised against it. The invention also provides a 414 amino acid form of PAI-2 wherein the N-terminal methionine residue is deleted, a 60 kD glycosylated secreted recombinant form of PAI-2 and compositions and methods using these molecules. The invention further relates to a novel synthetic signal peptide.
L'invention se rapporte à l'inhibiteur d'activateur de plasminogène de type 2 et à son expression comme molécule recombinante dans des lignées de cellules eukaryotiques sous la forme d'une molécule sécrétée glycosylée, aux structures permettant son expression, à des cellules hôtes effectuant son expression, à des compositions le contenant, à des procédés de traitement, de prophylaxie et de diagnostic l'utilisant et à des anticorps dressés contre lui. L'invention se rapporte également à une forme de 414 acides aminés du PAI-2, dans laquelle le résidu de méthionine de terminaison N est supprimé, à une forme recombinante sécrétée glycosylée de 60 kD du PAI-2 et à des compositions et des procédés utilisant ces molécules. L'invention se rapporte en outre à un nouveau peptide de signal synthétique.
Bunn Clive L.
Richardson Michael A.
Whitfeld Peter L.
Bereskin & Parr
Biotechnology Australia Pty. Ltd.
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