C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/525 (2006.01) A61K 38/19 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2563754
The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.
L'invention concerne des polypeptides comprenant comme constituant A, au moins trois monomères d'un membre de la famille de ligands TNF et comme constituant B, au moins deux lieurs de peptide. Les lieurs de peptide combinent les monomères du membre de la famille des ligands TNF. L'invention concerne en outre l'utilisation de ces peptides pour traiter des affections, pour produire un médicament ou un vaccin. L'invention concerne par ailleurs des procédés permettant de produire et isoler lesdits polypeptides, ainsi que des acides nucléiques codant lesdits polypeptides, des vecteurs les contenant, des cellules hôtes transfectées par lesdits vecteurs et des compositions pharmaceutiques qui contiennent lesdits objets de l'invention. Pour finir, l'invention concerne des procédés de manipulation extracorporelles, de déplétion et/ou d'élimination de constituants contenus dans des liquides organiques, par ex. par aphérèse.
Grunwald Ingo
Krippner-Heidenreich Anja
Pfizenmaier Klaus
Scheurich Peter
Mbm Intellectual Property Law Llp
Universitat Stuttgart
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