Recombinant polyvalent vaccine

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) A61K 39/25 (2006.01) A61P 31/22 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/38 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2630770

Disclosed are recombinant varicella-zoster virus, a process for producing the virus, a pharmaceutical composition comprising the recombinant varicella- zoster virus, a vector having a BAC vector sequence in a specific gene of the varicella-zoster virus genomic gene, a cell having the vector therein, a fragment capable of homologous recombination with the varicella-zoster virus genome, a nucleic acid cassette comprising a BAC vector sequence, and a polyvalent vaccine. A process for producing a recombinant varicella-zoster virus having a BAC vector sequence inserted in a specific viral gene.

L'invention concerne un virus varicella-zoster recombiné, un procédé servant à produire le virus, une composition pharmaceutique comprenant le virus varicella-zoster recombiné, un vecteur ayant une séquence vecteur BAC dans un gène spécifique du gène génomique du virus varicella-zoster, une cellule ayant le vecteur dans celle-ci, un fragment capable d'une recombinaison homologue avec le génome du virus varicella-zoster, une cassette d'acides nucléiques comprenant une séquence vecteur BAC et un vaccin polyvalent. L'invention concerne également un procédé servant à produire un virus varicella-zoster recombiné ayant une séquence vecteur BAC insérée dans un gène viral spécifique.

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