C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01)
Patent
CA 2282300
Recombinant pox viruses capable of expressing an immunogenic fragment of the MUC1 tumor-associated antigen are disclosed. The recombinant viruses can be used as vaccines to prevent the establishment of or treat tumors or pre- tumorous cells expressing the MUC1 tumor-associated antigen. The vaccines can be provided as an admixture comprising: (1) a recombinant pox virus encoding the immunogenic fragment of the MUC1 tumor-associated antigen, and (2) a recombinant pox virus encoding a T-cell co-stimulatory factor. The vaccine admixture can be used, e.g., to prevent establishment of tumors or pre- tumorous cells expressing the MUC1 tumor-associated antigen. The MUC1 specific cytotoxic T-cells can be isolated and expanded and used in a method for treating a host having a tumor expressing MUC1 positive tumor cells.
L'invention concerne des poxvirus recombinés, capables d'exprimer un fragment immunogène de l'antigène associé aux tumeurs MUC1. Les virus recombinés peuvent être utilisés comme vaccins afin de prévenir ou traiter l'établissement de tumeurs ou de cellules prétumorales exprimant l'antigène associé aux tumeurs MUC1. Les vaccins peuvent être un mélange renfermant: (1) un poxvirus recombiné codant pour le fragment immunogène de l'antigène associé aux tumeurs MUC1, et (2) un poxvirus codant pour un facteur co-activateur de cellules T. Le mélange vaccinal peut être utilisé, p. ex., pour prévenir l'établissement de tumeurs ou de cellules prétumorales exprimant l'antigène associé aux tumeurs MUC1. Les lymphocytes T cytotoxiques spécifiques de MUC1 peuvent être isolés, multipliés, et utilisés dans un procédé permettant de traiter un hôte présentant une tumeur exprimant des cellules tumorales à MUC1 positif.
Gritz Linda
Kantor Judith
Kufe Donald
Panicali Dennis
Schlom Jeffrey
Dana-Farber Cancer Institute Inc.
Department Of Health And Human Services The Government Of The United States Of America Represented By Th
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Therion Biologics Corporation
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