Recombinant poxvirus-calicivirus [rabbit hemorrhagic disease...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/01 (2006.01) A61K 39/125 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) C07K 14/08 (2006.01) C07K 14/085 (2006.01) C07K 16/10 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2223419

Attenuated recombinant viruses containing DNA encoding a calicivirus antigen such as a RHDV antigen, e.g., a capsid gene, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA from the viruses can be used for probes or for primers.

La présente invention concerne des virus de recombinaison atténués contenant un ADN codant un antigène de calicivirus tel qu'un antigène RHDV, par exemple un gène à capside. L'invention concerne également des procédés et des compositions utilisant ces virus, leurs produits d'expression, et des anticorps issus de ces virus ou de leurs produits d'expression. Ces virus de recombinaison, qui peuvent être de type NYVAC ou de type ALVAC, et les produits géniques qui en sont issus, ainsi que les anticorps issus de ces virus et de ces produits géniques conviennent particulièrement à une utilisation préventive, thérapeutique et diagnostique. L'ADN provenant de ces virus convient à la réalisation de sondes ou d'amorces.

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