Recombinant poxvirus - cytomegalovirus compositions and uses

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/01 (2006.01) A61K 39/245 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) C07K 14/045 (2006.01) C07K 14/065 (2006.01) C07K 14/07 (2006.01) C07K 14/145 (2006.01) C07K 16/08 (2006.01) C12N 7/04 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2223282

Attenuated recombinant viruses containing DNA encoding an HCMV antigen, as well as methods and compositions employing the viruses, expression products therefrom, and antibodies generated from the viruses or expression products, are disclosed and claimed. The recombinant viruses can be NYVAC or ALVAC recombinant viruses. The recombinant viruses and gene products therefrom and antibodies generated by the viruses and gene products have several preventive, therapeutic and diagnostic uses. The DNA of the recombinant viruses can be used as probes or for generating PCR primers.

L'invention concerne des virus de recombinaison atténués contenant de l'ADN codant un antigène de CMV humain, ainsi que des méthodes et des compositions dans lesquelles lesdits virus sont utilisés, des produits d'expression de ces derniers et des anticorps générés à partir desdits virus ou desdits produits d'expression. Les virus de recombinaison peuvent être des virus de recombinaison NYVAC ou ALVAC. Les virus de recombinaison et leurs produits géniques ainsi que les anticorps générés par ceux-ci ont plusieurs applications préventives, thérapeutiques et diagnostiques. L'ADN des virus de recombinaison selon l'invention peut être utilisé comme sonde ou pour générer des amorces à PCR.

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