C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/863 (2006.01) A61K 39/12 (2006.01) C07K 14/07 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01)
Patent
CA 2481799
The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing , an immune response in a living animal, including a human, is provided.
L'invention concerne un vecteur de poxvirus recombinant capable d'exprimer au moins deux séquences homologues étrangères, dérivant de divers variants d'un micro-organisme et possédant une homologie d'au moins 50 %. L'invention concerne également un procédé de préparation d'un tel poxvirus recombinant et l'utilisation de celui-ci comme médicament ou vaccin. L'invention concerne enfin un procédé permettant d'influer sur une réponse immune, de préférence, d'induire une réponse immune chez un animal vivant, notamment un être humain.
Howley Paul
Leyrer Sonja
Bavarian Nordic A/s
Goudreau Gage Dubuc
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