Recombinant preparation of bromelain inhibitors and...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2730659

The present invention pertains in general to Bromelain and particularly to the active compounds contained in this complex mixture of proteins. The present invention provides recombinant expressed Bromelain inhibitor precursor and Bromelain inhibitors, which are found in Bromelain. It has been found that the recombinant expressed inhibitors have superior effects in terms of treatment of disorders and conditions than Bromelain or its protein fractions from plant extracts.

L'invention concerne de manière générale la bromélaïne, et en particulier, les composés actifs contenus dans ce mélange complexe de protéines. Elle se réfère à un précurseur d'inhibiteur de la bromélaïne et à des inhibiteurs de la bromélaïne exprimés par recombinaison, qui sont présents dans la bromélaïne. Les inhibiteurs exprimés par recombinaison possèdent des effets supérieurs dans le traitement de troubles et d'états pathologiques, par rapport à la bromélaïne ou à des fractions de protéine provenant d'extraits végétaux.

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