Recombinant preparation of calcitonin fragments and use...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/16 (2006.01) C07K 14/585 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2245681

A process for the recombinant preparation of a calcitonin fragment and the use of the fragment in the preparation of calcitonin and related analogs is provided. The process includes recombinantly forming a fusion protein which includes the calcitonin fragment linked to a carbonic anhydrase. The recombinantly formed fusion protein is subsequently cleaved to produce a polypeptide which includes the calcitonin fragment. A method for producing a calcitonin carba analog which includes condensing a desaminononapeptide with the recombinantly formed calcitonin fragment is also provided.

L'invention concerne un procédé de préparation par recombinaison d'un fragment de calcitonine et l'utilisation dudit fragment pour la préparation de calcitonine et d'analogues apparentés. Selon le procédé, on produit par recombinaison une protéine de fusion qui contient le fragment de calcitonine lié à une anhydrase carbonique. Puis on sépare la protéine de fusion produite par recombinaison, de façon à produire un polypepetide contenant le fragment de calcitonine. L'invention concerne également un procédé permettant de produire un carba-analogue de la calcitonine, selon lequel on condense un désamino-nonapeptide avec le fragment de calcitonine produit par recombinaison.

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