Recombinant protein containing a c-terminal fragment of...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/30 (2006.01) A61K 39/015 (2006.01) C07K 1/22 (2006.01) C07K 14/445 (2006.01) C07K 16/20 (2006.01) C12N 5/18 (2006.01) C12N 15/86 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2245727

The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 42 kilodaltons (p42) of the surface protein 1 (protein MSP-1) of the merozoite form of a parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said p42 fragment being particularly deleted of its region II and, if necessary, also of its region III. Said recombinant protein is applicable to the production of vaccines against malaria.

L'invention concerne une protéine recombinante, fabriquée dans un système à baculovirus, dont la séquence polypeptidique constitutive essentielle est celle d'un fragment C-terminal de 42 kilodaltons (p42) de la protéine 1 de surface (protéine MSP-1) de la forme mérozoïte d'un parasite du type Plasmodium, en particulier Plasmodium falciparum, infectieux pour l'Homme, ce fragment p42 étant particulièrement délété de sa région II et, le cas échéant, aussi de sa région III. Cette protéine recombinante est applicable à la production de vaccins contre la malaria.

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