C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/505 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2370477
The present invention provides methods and compositions for the production of recombinant proteins in a human cell line, using sequences encoding at least one E1 protein of an adenovirus where the cells does not encode a structural adenoviral protein from its genome. The methods and compositions are particularly useful for generating stable expression of human recombinant proteins of interest that are modified post-translationally, e.g. by glycosylation. Such proteins may have advantageous properties in comparison with their counterparts produced in non-human systems like Chinese Hamster Ovary (CHO) cells.
Ces méthodes et les compositions correspondantes, permettant de produire des protéines de recombinaison dans une lignée cellulaire, se révèlent des plus utiles pour exprimer de façon stable des protéines humaines de recombinaison modifiées après translation, par exemple par glycosylation. Ces protéines ont des caractéristiques supérieures comparé à leurs homologues produites dans des systèmes non humain, notamment dans les cellules ovariennes de hamster chinois.
Bout Abraham
Hateboer Guus
Schouten Govert Johan
Uytdehaag Alphonsus Gerardus Cornelis Maria
Verhulst Karina Cornelia
Borden Ladner Gervais Llp
Crucell Holland B.v.
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