Recombinant rabbit tissue factor based prothrombin time reagent

Details Recombinant rabbit tissue factor based prothrombin time reagent Recombinant rabbit tissue factor based prothrombin time reagent

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) C07K 14/705 (2006.01) C12Q 1/56 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2288058

Liquid and lyophilized reagents for determining prothrombin time and/or fibrinogen levels in a plasma sample are disclosed. The reagents preferably are based on recombinant rabbit tissue factor. Also disclosed is a purified preparation of recombinant rabbit tissue factor having unique properties, and a novel method for making PT reagents.

On décrit des réactifs liquides et lyophilisés permettant de déterminer le temps de prothrombine et/ou le taux de fibrinogène dans un échantillon de plasma. Les réactifs sont de préférence à base d'un facteur tissulaire recombiné de lapin. On décrit également une préparation purifiée de facteur tissulaire recombiné de lapin présentant des propriétés uniques, ainsi qu'un nouveau procédé de préparation de réactifs servant à la détermination du temps de prothrombine.

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