C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/21 (2006.01) A61K 39/275 (2006.01) A61K 39/295 (2006.01) A61P 31/12 (2006.01) C07K 14/155 (2006.01) C12N 15/863 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2224257
The present invention provides recombinant raccoon poxviruses (RRPVs) useful in vaccines for the prophylaxis of disease caused by feline immunodeficiency virus (FIV). RRPVs according to the invention have at least one internal gene comprising a DNA sequence that encodes FIV gag protein (gag), FIV enveloppe protein (env), a polypeptide consisting of amino acids 1-735 of FIV env, or immunogenic fragments of any of the foregoing. The vaccines that comprise one or more of the FIV-expressing recombinant raccoon poxviruses described above may also comprise a pharmaceutically acceptable carrier or diluent and a pharmaceutically acceptable adjuvant. The invention also provides methods for preventing or lessening disease caused by FIV, which is carried out by administering to a feline in need of such treatment the vaccines described above.
L'invention concerne des poxyvirus recombinés du raton laveur (RRPVs) utiles dans les vaccins pour la prophylaxie de maladies causées par le virus de l'immunodéficience féline (VIF). Les RRPVs, selon cette invention, possèdent au moins un gène interne comprenant une séquence d'ADN qui code pour la protéine gag du VIF (gag), la protéine enveloppe du VIF (env), un polypeptide formé des acides aminés 1-735 d'env du VIF, ou des fragments immunogènes de l'une quelconque des substances précitées. Les vaccins qui comprennent un ou plusieurs poxvirus recombinés du raton laveur exprimant le VIF décrits plus haut peuvent également comprendre un vecteur ou un diluant pharmaceutiquement acceptable ainsi qu'un adjuvant pharmaceutiquement acceptable. L'invention décrit également des procédés pour la prévention ou la réduction de maladies causées par le VIF, consistant à administrer à un félin nécessitant ce type de traitement les vaccins précités.
Chavez Lloyd George Jr.
Chu Hsien-Jue
Wasmoen Terri
American Home Products Corporation
Ridout & Maybee Llp
Wyeth
LandOfFree
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