Recombinant, replication defective celo virus and celo virus...

Details Recombinant, replication defective celo virus and celo virus... Recombinant, replication defective celo virus and celo virus...

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 35/76 (2006.01) C07K 14/075 (2006.01) C07K 14/465 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2384805

Recombinant CELO virus or CELO virus DNA with a deletion or disruption of the Gam1 gene, optionally combined with deletions at the right or left end of the viral genome that allow insertion of large pieces of foreign DNA. The virus is useful as a vaccine for animals, in particular birds, and for gene therapy and vaccine applications in humans. The virus can also be used for recombinant protein production.

L'invention concerne le virus CELO recombinant ou l'ADN du virus CELO présentant une délétion ou une disruption du gène Gam1 éventuellement combinée avec des délétions situées à l'extrémité droite ou gauche du génome viral et permettant l'insertion de grands morceaux d'ADN étranger. Ce virus est utile comme vaccin pour les animaux, notamment les oiseaux, ou pour des applications de thérapie génique et de vaccin chez les humains. Le virus peut également être utilisé pour la production de protéine recombinante.

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