C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 31/7088 (2006.01) A61K 39/155 (2006.01) A61K 48/00 (2006.01) C07K 14/135 (2006.01) C12N 7/04 (2006.01) C12N 15/45 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2430115
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to teh attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
La présente invention concerne des virus et des vecteurs viraux respiratoires syncytiaux de recombinaison mis au point par génie génétique contenant des délétions de divers gènes viraux accessoires soit de manière individuelle ou en combinaison. Selon la présente invention, les vecteurs viraux et les virus respiratoires syncytiaux de recombinaison sont mis au point de manière à contenir des délétions complètes des gènes viraux accessoires M2-2, NS1, NS2, ou SH ou diverses combinaisons de ceux-ci. De plus, la présente invention concerne l'atténuation d'un virus respiratoire syncytial par mutagenèse du gène M2-1.
Bryant Martin
Jin Hong
Li Shengqiang
Tang Roderick
Aviron Inc.
Osler Hoskin & Harcourt Llp
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