A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/155 (2006.01) C12N 7/04 (2006.01) C12N 7/06 (2006.01) C12N 7/08 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2380108
The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to the attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
La présente invention concerne des virus respiratoires syncytials (RS) et des vecteurs viraux contenant des délétions de divers gènes viraux accessoires seuls ou en combinaison. Selon la présente invention, les vecteurs viraux et les virus respiratoires syncytials recombinants sont modifiés de manière à contenir des délétions achevées des gènes viraux accessoires M2-2, NS1, NS2, ou SH, ou de leurs diverses combinaisons. En outre, la présente invention concerne l'atténuation du virus respiratoire syncytial par mutagenèse du gène M2-1.
Bryant Martin
Jin Hong
Li Shengqiang
Tang Roderick
Aviron
Osler Hoskin & Harcourt Llp
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