Recombinant rsv virus expression systems and vaccines

Details Recombinant rsv virus expression systems and vaccines Recombinant rsv virus expression systems and vaccines

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) C07K 14/135 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2304932

The present invention relates to genetically engineered recombinant RS viruses and viral vectors which contain heterologous genes which for the use as vaccines. In accordance with the present invention, the recombinant RS viral vectors and viruses are enginnerred to contain heterologous genes, including genes of other viruses, pathogens, cellular genes, tumor antigens, or to encode combinations of genes from different strains of RSV.

Cette invention se rapporte à des virus et à des vecteurs viraux RS (respiratoire syncytial) de recombinaison génétiquement modifiés, qui contiennent des gènes hétérologues destinés à servir de vaccins. Selon cette invention, ces vecteurs viraux et ces virus RS de recombinaison sont modifiés par génie génétique de façon à contenir des gènes hétérologues, y compris des gènes d'autres virus, des agents pathogènes, des gènes cellulaires et des antigènes tumoraux, ou pour coder des combinaisons de gènes provenant de différentes souches du virus respiratoire syncytial (RS).

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