Recombinant specific binding protein

Details Recombinant specific binding protein Recombinant specific binding protein

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/46 (2006.01) G01N 33/563 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2146854

A specific binding protein having first and second binding regions, e.g. antibody Fv frag- ments, which specifically recognise and bind to target entities, said binding regions being con- tained at least in part on respectively first and second polypeptide chains, said chains addition- ally incorporating respectively first and second associating domains, e.g. antibody VH and VL domains, which are capable of binding to each other, causing the first and second polypep- tide chains to combine, thereby providing a single protein incorporating the binding specif- icities of said first and second binding regions. The first and second binding regions may re- cognise different target entities, giving a bispecific binding protein. Preferably the associat- ing domains are derived from a human protein (i.e. one which has been exposed to the human immune system), so that the protein is less likely to provoke the human immune sys- tem when administered therapeutically. The binding protein is suitably produced by recom- binant DNA expression.

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