C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 2/00 (2006.01) A61K 9/00 (2006.01) A61K 39/12 (2006.01) A61K 39/15 (2006.01) A61K 39/44 (2006.01) A61K 47/42 (2006.01) A61P 37/02 (2006.01) C07K 14/18 (2006.01) C07K 14/435 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/866 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2382176
A method is provided of producing an immunogenic complex comprising a heat shock protein (hsp) coupled to a heterologous antigenic polypeptide, which method comprises: (a) expressing the antigenic polypeptide in a cell which cell has been subjected to a stimulus which causes the induction of a heat shock response in said cells; and (b) recovering the antigenic polypeptide coupled to one or more hsps from said cell or the culture medium. Also provided are immunogenic compositions comprising a heat shock protein (hsp) derived from a non-mammalian eukaryote coupled to a heterologous antigenic polypeptide which composition is capable of inducing an immune response to said antigenic polypeptide in a human or animal.
L'invention concerne une méthode de production d'un complexe immunogénique contenant une protéine de stress (hsp) couplée à un polypeptide antigénique hétérologue. Ladite méthode consiste à (a) exprimer le polypeptide antigénique dans une cellule qui a été sujette à un stimulus provoquant l'induction d'une réponse de stress dans ladite cellule, et (b) récupérer le polypeptide antigénique couplé à au moins une hsp de ladite cellule ou du milieu de culture. Cette invention concerne également des compositions immunogéniques contenant une protéine de stress (hsp) dérivée d'un eucaryote non mammalien couplé à un polypeptide antigénique hétérologue. Ladite composition est capable d'induire une réponse immunitaire dans un polypeptide antigénique chez un être humain ou un animal.
Colaco Camilo Anthony Leo Selwyn
Frost Melinda Jane
Shannon Anthony Douglas
Mbm Intellectual Property Law Llp
Minister For Agriculture Minister For Land And Water Conservation For A. Nd On Behalf Of
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