Recombinant systems for expressions of cholera b-subunit...

C - Chemistry – Metallurgy – 12 – N

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530/13, 167/135,

C12N 15/62 (2006.01) A61K 39/106 (2006.01) A61K 39/385 (2006.01) C07K 14/245 (2006.01) C07K 14/28 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 15/31 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01)

Patent

CA 1340577

Procedures are described whereby with the aid of recombinant DNA methods the expression of the binding subunit protein of cholera toxin (CTB) or derivatives thereof including hybrid gene fusion proteins to CTB has been brought under control of a foreign (non-cholera toxin) promoter and/or the CTB protein or its derivatives is being synthesized with a foreign rather than the natural leader peptide to facilitate translocation across cell membranes.

611596

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