Recombinant therapeutic fusion proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/62 (2006.01) A61K 39/165 (2006.01) C07K 14/12 (2006.01) C07K 14/47 (2006.01) C12N 9/12 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2389339

A recombinant bifunctional fusion protein comprises a first component which is the antigenic ectodomain of measles virus hemagglutin protein (MeaH) genetically modified not to bind to human cells; and a second component fused thereto which is capable of binding to the surface structure of genetically variable viruses such as HCV or HIV or other therapeutic targets. The second component binds to the target and the first component is recognised by anti- measles antibodies present in the majority of the population. The protein may be used therapeutically to treat HCV or HIV infection or against other therapeutic targets.

L'invention porte sur une protéine de fusion bifonctionnelle de recombinaison comprenant un premier composant, l'ectodomaine antigénique de la protéine hémagglutinine du virus de la rougeole, génétiquement modifiée de façon à ne pas se lier à des cellules humaines; ainsi que sur un second composant fusionné à celui-ci, capable de se lier à la structure superficielle des virus génétiquement variables, tels que le VHC et le VIH ou d'autres cibles thérapeutiques. Le second composant se lie à la cible, alors que le premier composant est reconnu par des anticorps contre la rougeole présents dans la majorité de la population. La protéine peut être utilisée sur le plan thérapeutique pour traiter le VHC ou l'infection par VIH ou contre d'autres cibles thérapeutiques.

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