Recombinant thrombin receptor and related pharmaceuticals

Details Recombinant thrombin receptor and related pharmaceuticals Recombinant thrombin receptor and related pharmaceuticals

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/04 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C07K 5/10 (2006.01) C07K 7/04 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 9/74 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2104394

2104394 9214750 PCTABS00015 The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thrombin agonists and antagonists. Further, the elucidation of the structure of the thrombin receptor permits the design of agonist and antagonist compounds which are useful diagnostically and therapeutically. The availability of the thrombin receptor also permits production of antibodies specifically immunoreactive with the receptor per se or with specific regions thereof which are also useful diagnostically or therapeutically.

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