Recombinant transferrin mutants

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/79 (2006.01) C12N 5/071 (2010.01) A61K 38/16 (2006.01) A61K 38/40 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2690905

The present invention provides a recombinant protein comprising the sequence of a transferrin mutant, wherein Ser415 is mutated to an amino acid which does not allow glycosylation at Asn413 and/or wherein Thr613 is mutated to an amino acid which does not allow glycosylation as Asn61 1. It also provides polynucleotides encoding the same and methods of making and using said recombinant protein.

La présente invention concerne une protéine recombinante comprenant la séquence d'un mutant de la transferrine dans laquelle le codon Ser415 est modifié en un acide aminé ne permettant pas la glycosylation au niveau de Asn413 et/ou le codon Thr613 est modifié en un acide aminé ne permettant pas la glycosylation au niveau de Asn611. L'invention concerne en outre des polynucléotides codant la protéine recombinante et des méthodes de production et d'utilisation de celle-ci.

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