Recombinant tumor specific antibody and use thereof

Details Recombinant tumor specific antibody and use thereof Recombinant tumor specific antibody and use thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2446087

The invention provides a family of antibodies that specifically bind the human epithelial cell adhesion molecule. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies, when coupled to the appropriate moiety, may be used in the diagnosis, prognosis and treatment of cancer.

Cette invention se rapporte à une famille d'anticorps qui se fixent spécifiquement à la molécule d'adhésion cellulaire épithéliale humaine. Ces anticorps comprennent des régions variables modifiées et, plus spécifiquement, des régions de charpente modifiées, qui réduisent leur immunogénicité, lorsqu'ils sont administrés à un sujet humain. Lorsqu'ils sont couplés à la fraction appropriée, ces anticorps peuvent servir dans le diagnostic, le pronostic et le traitement du cancer.

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