C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A61K 38/54 (2006.01) C07H 21/04 (2006.01) C12N 9/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2337967
The present invention relates, in general, to urate oxidase (uricase) proteins and nucleic acid molecules encoding same. In particular, the invention relates to uricase proteins which are particularly useful as, for example, intermediates for making improved modified uricase proteins with reduced immunogenicity and increased bioavailability.
La présente invention concerne, en général, des protéines urate-oxydases (uricases) et des molécules d'acide nucléique codant ces protéines. L'invention concerne en particulier des protéines uricases particulièrement utiles, par exemple, comme intermédiaires entrant dans la fabrication de protéines uricases modifiées améliorées présentant une immunogénicité réduite et une biodisponibilité accrue.
Hershfield Michael
Kelly Susan J.
Duke University
Goudreau Gage Dubuc
LandOfFree
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