C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 39/08 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/33 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2371279
This invention is directed to preparation and expression of synthetic genes encoding polypeptides containing protective epitopes of botulinum neurotoxin (BoNT). The invention is also directed to production of immunogenic peptides encoded by the synthetic genes, as well as recovery and purification of the immunogenic peptides from recombinant organisms. The invention is also directed to methods of vaccination against botulism using the expressed peptides.
La présente invention concerne la préparation et l'expression de gènes de synthèse codant des polypeptides contenant des épitopes protecteurs de neurotoxine botulique (BoNT). L'invention porte également sur la production de peptides immunogènes codés par ces gènes de synthèse, de même que la récupération et la purification de peptides immunogènes à partir d'organismes de recombinaison. L'invention concerne enfin des procédés de vaccination contre la neurotoxine botulique utilisant les peptides exprimés.
Brown Douglas R.
Byrne Michael P.
Clayton Michael A.
Lapenotiere Hugh
Middlebrook John L.
Smart & Biggar
United States Army Medical Research & Materiel Cmd
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