Recombinant vascular endothelial cell growth factor d (vegf-d)

Details Recombinant vascular endothelial cell growth factor d (vegf-d) Recombinant vascular endothelial cell growth factor d (vegf-d)

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 14/49 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2263890

VEGF-D, a new member of the PDGF family of growth factors, which among other things stimulates endothelial cell proliferation and angiogenesis and increases vascular permeability, is described, as well as nucleotide sequences encoding it, methods for producing it, antibodies and other antagonists to it, transfected or transformed host cells for expressing it, pharmaceutical compositions containing it, and uses thereof in medical and diagnostic applications.

L'invention concerne VEGF-D, nouveau membre de la famille PDGF (facteurs de croissance d'origine plaquettaire) des facteurs de croissances qui stimule, entre autres, la prolifération et l'angiogenèse des cellules endothéliales et favorise la perméabilité vasculaire, ainsi que des séquences nucléotidique codant pour ledit facteur, des méthodes de fabrication dudit facteur, ses anticorps et autres antagonistes, des cellules hôtes transfectées ou transformées exprimant ledit facteur, des compositions pharmaceutiques comprenant ledit facteur et ses utilisations dans des applications médicales et diagnostiques.

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