C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 14/54 (2006.01) C07K 14/545 (2006.01) C12N 7/01 (2006.01) C12N 9/12 (2006.01) C12N 15/861 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2156132
The invention provides novel vectors derived from adenovirus which are specifically suitable for use in methods of gene therapy. The vectors have a deletion compared to wild-type adenovirus in that the E1 region is not present in a functional manner. Additionally the vectors are characterized in that they do contain a part of the E3 region of adenovirus which is biologically functional. This results in vectors which do normally not lead to expression of adenoviral proteins, but which in the cases where such proteins do become expressed will repress the host's immunological response to said proteins. Thereby host cells infected (provided) with the vector will live longer. Therefore, the product introduced into said cells providing the therapy will be produced in larger amounts, or at least for a prolonged period. Preferably the vector comprises genetic information for antisense therapy, or for genes which will combat tumors, such as genes encoding cytokines, preferably IL-1, or so called suicide genes, such as Herpes Simplex Virus thymidine kinase. Methods for producing said vectors and methods of gene therapy or uses therein are also disclosed.
Bout Abraham
Valerio Domenico
Van Bekkum Dirk Willem
Borden Ladner Gervais Llp
Crucell Holland B.v.
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