C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/63 (2006.01) A61K 39/12 (2006.01) A61K 39/295 (2006.01) C07K 14/18 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2329133
A prophylactic or therapeutic vaccine for use in protecting mammals such as humans or animals against Venezelan Equine Encephalitis virus (VEE) is described. In particular, the vaccine comprises a recombinant virus such as a recombinant vaccinia virus which is able to express the structural genes of VEE in attenuated form, which has been modified to increase the protective effect of the vaccine. This is achieved by modifying the sequence of the attenuated VEE strain and/or putting this under the control of modified promoter which increases expression from the vector. Formulations of the vaccine as well as methods of treatment using the vaccine are also described.
L'invention concerne un vaccin prophylactique ou thérapeutique destiné à protéger les mammifères, humains ou animaux, contre le virus de l'encéphalite équine du Venezuela (VEE). En particulier, le vaccin comprend un virus recombinant, tel qu'un virus vaccinal recombinant capable d'exprimer les gènes de structure du VEE sous forme atténuée, qui peut être modifié pour accroître l'effet protecteur du vaccin. Ceci est obtenu en modifiant la séquence de la souche VEE atténuée et/ou en la plaçant sous le contrôle d'un promoteur modifié qui accroît l'expression à partir du vecteur. L'invention concerne également des formulations du vaccin ainsi que des procédés de traitement utilisant ledit vaccin.
Fetherstonhaugh & Co.
The Secretary Of State For Defence In Her Britannic Majesty's Go
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