Recombinant virus expressing carcinoembryonic antigen and...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61K 39/285 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2102623

The present invention relates to a recombinant carcinoembryonic antigen (CEA)/vaccinia virus or other viral vector which expresses GEA on the surface of infected cells and which elicits an immune response in vivo directed against CEA or cells ex- pressing CEA an d a pharmaceutical composition containing same. The invention also relates to methods of treating patients con- taining carcinoma cells in which CEA is expressed and methods of stimulating the immune system against CEA.

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