Recombinant virus vector for gene introduction in lymphocyte

Details Recombinant virus vector for gene introduction in lymphocyte Recombinant virus vector for gene introduction in lymphocyte

C - Chemistry, Metallurgy

12

N

C12N 15/38 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) A61P 31/18 (2006.01) C12N 1/21 (2006.01) C12N 7/01 (2006.01)

Patent

CA 2565509

It is intended to provide a recombinant herpesvirus; a process for producing the same; and a pharmacological composition comprising a recombinant herpesvirus. Further, it is intended to provide a vector comprising a herpesvirus genome gene and a BAC vector sequence; a cell comprising such a vector; a fragment capable of homologous recombination with herpesvirus genome; and a nucleic acid cassette comprising a BAC vector sequence. The objects have been attained by the development of a process for producing a recombinant herpesvirus in which use is made of a BAC vector sequence.

Il est prévu de fournir un virus de l'herpès recombinant ; un processus pour le produire ; une composition pharmacologique comprenant un virus de l'herpès recombinant. Il est également prévu de fournir un vecteur comprenant un gène du génome du virus de l'herpès et une séquence de vecteur BAC ; une cellule comprenant ce vecteur ; un fragment capable d'une recombinaison homologue avec génome du virus de l'herpès ; une cassette d'acide nucléique comprenant une séquence de vecteur BAC. Les objets ont été obtenus par le développement d'un processus permettant de produire un virus de l'herpès recombinant dont l'utilisation est constituée d'une séquence de vecteur BAC.

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