Recombinantly modified plasmin

Details Recombinantly modified plasmin Recombinantly modified plasmin

C - Chemistry, Metallurgy

12

N

C12N 9/68 (2006.01) C12N 5/10 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2563675

Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

L'invention concerne des polynucléotides et des polypeptides relatifs à une molécule de plasmine (plasminogène) à modification par recombinaison. Ladite molécule comporte une terminaison N de domaine kringle unique sur le site d'activation présent dans la molécule plasminogène humaine d'origine et présente des propriétés de liaison avec la lysine et des caractéristiques enzymatiques importantes associées à l'enzyme d'origine.

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