Recombinantly modified plasmin

Details Recombinantly modified plasmin Recombinantly modified plasmin

C - Chemistry, Metallurgy

12

N

C12N 9/68 (2006.01) C12N 15/09 (2006.01)

Patent

CA 2707266

Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site present in the native human plasminogen molecule, combined such that no foreign sequences are present, and exhibits lysine-binding and significant enzymatic characteristics associated with the native enzyme.

L'invention concerne des polynucléotides et des polypeptides apparentés à une molécule de plasmine (plasminogène) modifiée de manière recombinante. La molécule de plasmine (plasminogène) a une extrémité N-terminale à domaine kringle unique vers le site d'activation présent dans la molécule de plasminogène humaine native, combinée de telle sorte qu'il n'y a pas de séquences étrangères, et présente une liaison à la lysine et des caractéristiques enzymatiques significatives associées à l'enzyme native.

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